Lincoln Clinical Trials Unit (LinCTU)

Please find below our current and recent projects supported by the Lincoln Clinical Trials Unit:
Active projects

The Lifeguard Study: Responding to people in danger. A feasibility study to co-develop a community pharmacy response service for domestic violence and suicidal ideation 2021-2023
Funded by NIHR Research for Patient Benefit, awarding £370,459. Key contact: Prof Graham Law.
The main aim of this study is to co-develop and evaluate the feasibility of a community pharmacy response service / intervention for people in danger from domestic violence or suicidal ideation.


Strengthening Mental Abilities with Relational Training in Multiple Sclerosis: A feasibility trial (SMART MS) 2021-2022
Funded by NIHR Research for Patient Benefit, awarding £149,377. Key contact: Prof Graham Law.
The main aim of this study is to develop and conduct feasibility and pilot studies exploring Strengthening Mental Abilities with Relational Training (SMART) for people with MS.


Effect of implementing an ambulance clinician delivered hypoglycaemia intervention (‘Hypos can strike twice’) on repeat ambulance calls, attendances and transportation to hospital: non-randomised stepped wedge and process evaluation (Ambu-HS2) 2020-2022
Funded by the National Institute for Health Research (NIHR) Applied Research Collaboration East Midlands, awarding £200,000. Key contact: Professor Niro Siriwardena
This is a non-randomised stepped wedge study with a mixed-methods process evaluation study which aims to evaluate the effect of implementing the ‘Hypo’s can strike twice’ intervention to patients with diabetes and hypoglycaemia attended by East Midlands Ambulance Service NHS Trust in the East Midlands region.


Community First Responders’ role in the current and future rural health and care workforce 2020-2022
Funded by the National Institute for Health Research (NIHR) Health Services and Delivery Research Programme, awarding £471,000. Key contact: Professor Niro Siriwardena
This is a mixed methods study which aims to work with PPI and stakeholders throughout to develop recommendations for future innovations in rural CFR provision by investigating current activity, costs of provision, and views of patients, public, CFR schemes and rural care providers.


Development of a patient-maintained sedation device to allow patients to safely control their own sedation levels during surgical and medical procedures (ACCEPTS) 2018-2020
Funded by the National Institute for Health Research (NIHR) Invention for Innovation (NIHR I4I), awarding £680,097. Key contact: Dr Murray D Smith
This is a clinical trial of Patient maintained propofol sedation (PMPS) during lower limb arthroplasty under spinal anaesthesia compared to standard care anaesthetist controlled propofol sedation.